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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2022 Association of Ultrafast Thrombolysis With Early Neurological Outcome in Acute Ischemic Stroke

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Authors

MHMarc HemmerichCHCarolin HoyerVSVesile Sandikci

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Overview

Retrospective analysis reports improved neurological outcomes with ultrafast thrombolysis in acute ischemic stroke, suggesting optimized care impacts recovery.

Key Points

  • This study aims to explore how different door-to-needle times affect neurological outcomes in acute ischemic stroke patients receiving thrombolysis.
  • Retrospective analysis of 669 IVT-treated acute ischemic stroke patients from 2021 to 2024.
  • Patients stratified by door-to-needle time into different groups for comparison.
  • Evaluation of demographics, NIHSS, and mRS scores across groups.
  • 30.8% of patients received ultrafast thrombolysis with a door-to-needle time of ≤20 min.
  • Significant differences in NIHSS at admission and discharge mRS (p=0.026 and p=0.030), with ultrafast group showing better outcomes.
  • Early neurological improvement decreased with longer door-to-needle times (median delta NIHSS, p<0.001).

Cite This Study

Hemmerich et al. (2026) studied this question.

synapsesocial.com/papers/69fd7ec6bfa21ec5bbf07175https://doi.org/10.1093/esj/aakag023.1707
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ABSTRACT NUMBER: ESOC2026A1757 FASTER IS BETTER EFFECT OF EMERGENCY DEPARTMENT INITIATED INTRAVENOUS THROMBOLYSIS ON DOOR TO NEEDLE TIME AND CLINICAL OUTCOMES IN A MOLDOVAN STROKE CENTER2026
  2. 2Association between door-to-needle time and outcomes in acute ischemic stroke patients treated with intravenous thrombolysis plus mechanical thrombectomy: Analysis from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS)2026 · 1 citations
  3. 3ABSTRACT NUMBER: ESOC2026A1751 TRENDS IN DOOR-TO-NEEDLE TIME FOLLOWING EXPANSION OF THROMBOLYSIS INDICATIONS IN ACUTE ISCHAEMIC STROKE2026
  4. 4ABSTRACT NUMBER: ESOC2026A1730 TIME-DEPENDENT EFFICACY OF THROMBOLYSIS BEFORE THROMBECTOMY: RESULTS FROM INTERNATIONAL REGISTRY OF STROKE CARE QUALITY (RES-Q)2026
  5. 5ABSTRACT NUMBER: ESOC2026A1576 INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKE: 2025 STATISTICAL ANALYSIS IN NEUROLOGY DEPARTMENT OF ”CAROL DAVILA” CENTRAL MILITARY EMERGENCY UNIVERSITY HOSPITAL2026