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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1757 Faster Is Better Effect of Emergency Department Initiated Intravenous Thrombolysis on Door to Needle Time and Clinical Outcomes in a Moldovan Stroke Center

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Authors

LALevca AnastasiaVSVeronica SpineiTSTatiana Stupac

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Overview

Retrospective study shows improved outcomes in stroke patients after ED-initiated thrombolysis, suggesting significant benefits in care delivery.

Key Points

  • The study aims to evaluate how initiating intravenous thrombolysis in the emergency department affects treatment times and patient outcomes.
  • Conducted a retrospective observational study from 2019 to 2025 in a tertiary stroke center.
  • Compared patients treated with intravenous thrombolysis before and after the implementation of ED-initiated thrombolysis.
  • Analyzed door-to-needle time, stroke severity (NIHSS), functional outcome (mRS), and hemorrhagic transformation rates.
  • Mean door-to-needle time decreased from 76 minutes to 44 minutes after implementation.
  • Patients showed lower NIHSS scores and greater neurological recovery post-implementation.
  • Functional outcomes improved with mRS median decreasing from 4 to 2; hemorrhagic transformation rates dropped from 31% to 15%.

Cite This Study

Anastasia et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f65bfa21ec5bbf07ec1https://doi.org/10.1093/esj/aakag023.824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ABSTRACT NUMBER: ESOC2026A2022 ASSOCIATION OF ULTRAFAST THROMBOLYSIS WITH EARLY NEUROLOGICAL OUTCOME IN ACUTE ISCHEMIC STROKE2026
  2. 2ABSTRACT NUMBER: ESOC2026A1576 INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKE: 2025 STATISTICAL ANALYSIS IN NEUROLOGY DEPARTMENT OF ”CAROL DAVILA” CENTRAL MILITARY EMERGENCY UNIVERSITY HOSPITAL2026
  3. 3ABSTRACT NUMBER: ESOC2026A1751 TRENDS IN DOOR-TO-NEEDLE TIME FOLLOWING EXPANSION OF THROMBOLYSIS INDICATIONS IN ACUTE ISCHAEMIC STROKE2026
  4. 4Abstract TP037: Reducing Door-to-Needle Times in the Emergency Department Through Optimized Code Stroke Workflow and Early CT Thrombolytic Administration2026
  5. 5ABSTRACT NUMBER: ESOC2026A1730 TIME-DEPENDENT EFFICACY OF THROMBOLYSIS BEFORE THROMBECTOMY: RESULTS FROM INTERNATIONAL REGISTRY OF STROKE CARE QUALITY (RES-Q)2026