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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1751 Trends in Door-to-Needle Time Following Expansion of Thrombolysis Indications in Acute Ischaemic Stroke

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Authors

LPLorena PhanTSTim SinneckerOIon Behalf of the Swiss Stroke Registry Investigators

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Overview

Randomized trial finds stable door-to-needle time in acute ischaemic stroke, indicating effective treatment adherence.

Key Points

  • This study aims to evaluate the trends in door-to-needle time (DNT) following expanded thrombolysis indications for acute ischaemic stroke.
  • Included 14,861 acute ischaemic stroke patients from the Swiss Stroke Registry between 2014 and 2023.
  • Analyzed DNT dynamics across subgroups and assessed associations with 90-day disability and mortality using multivariate regression and LASSO regression.
  • Recorded median DNT before and after 2021 ESO guideline implementation.
  • Median DNT was stable: 40 minutes (IQR 29–58) before 2021 vs. 39 minutes (IQR 29–57) after 2021, p=0.1966.
  • Prolonged DNT was linked to female sex (1.04 ratio, p=0.007), preexisting disability (1.05 ratio, p<0.001), and treatment with anticoagulants (1.49 ratio, p<0.001).
  • Each minute of prolonged DNT corresponded to a 0.12 increase in disability (mRS, p<0.001) and an odds ratio of 1.19 for mortality (p<0.001).

Cite This Study

Phan et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e79bfa21ec5bbf06a4bhttps://doi.org/10.1093/esj/aakag023.822
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ABSTRACT NUMBER: ESOC2026A1757 FASTER IS BETTER EFFECT OF EMERGENCY DEPARTMENT INITIATED INTRAVENOUS THROMBOLYSIS ON DOOR TO NEEDLE TIME AND CLINICAL OUTCOMES IN A MOLDOVAN STROKE CENTER2026
  2. 2Trends in Door-to-Thrombolysis Time in the Safe Implementation of Stroke Thrombolysis Registry2015 · 54 citations
  3. 3Association between door-to-needle time and outcomes in acute ischemic stroke patients treated with intravenous thrombolysis plus mechanical thrombectomy: Analysis from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS)2026 · 1 citations
  4. 4ABSTRACT NUMBER: ESOC2026A2022 ASSOCIATION OF ULTRAFAST THROMBOLYSIS WITH EARLY NEUROLOGICAL OUTCOME IN ACUTE ISCHEMIC STROKE2026
  5. 5ABSTRACT NUMBER: ESOC2026A986 DOOR-TO-NEEDLE TIMES AFTER ROUTINE TENECTEPLASE ADOPTION2026