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May 8, 2026American Journal of Health-System Pharmacy

Temporal and agent-level trends in opioid prescribing for patients with severe sickle cell disease

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Authors

KSKangho SuhRKRachel KimHKHyeun Ah Kang

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Overview

Retrospective cohort study reveals declining opioid prescribing trends in severely affected sickle cell disease patients, suggesting need for tailored stewardship strategies.

Key Points

  • This study aims to assess how opioid prescribing trends have changed over time for patients with severe sickle cell disease experiencing frequent vaso-occlusive crises.
  • Retrospective cohort study using electronic health records from 2014-2023.
  • Included adults (≥18 years) with 3 or more vaso-occlusive crises within a 12-month period.
  • Used mixed-effects logistic regression to analyze opioid use trends relative to calendar years.
  • Overall opioid prescribing declined significantly (odds ratio, 0.92 per year; 95% CI, 0.89-0.96).
  • Oxycodone saw the most consistent reduction over the study period.
  • Despite high clinical need, the probability of receiving opioids after a VOC episode decreased continuously.

Cite This Study

Suh et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f25bfa21ec5bbf07913https://doi.org/10.1093/ajhp/zxag134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Opioid Prescribing and Outcomes in Patients With Sickle Cell Disease Post–2016 CDC Guideline2024 · 28 citations
  2. 2Dynamic Changes in the Distribution of Hydrocodone and Oxycodone in Florida from 2006 to 20212024 · 1 citations
  3. 3The Opioid Drug Epidemic and Sickle Cell Disease: Guilt by Association2016 · 97 citations
  4. 4Management of Chronic Pain in Adults Living With Sickle Cell Disease in the Era of the Opioid Epidemic2019 · 90 citations
  5. 5Proportion of Adults With Sickle Cell Anemia and Pain Crises Receiving Hydroxyurea2015 · 69 citations