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December 8, 2025Blood

Correlation between outpatient opioid dosage and hospital visits in sickle cell disease patients

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Authors

EMElizabeth V. Minten

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Overview

Retrospective chart review shows increasing outpatient opioid doses correlate with more emergency department visits in sickle cell disease patients, suggesting poor pain management.

Key Points

  • Investigate the relationship between outpatient opioid prescriptions and hospital visits in sickle cell disease patients.
  • Conducted a retrospective chart review of 237 patients with sickle cell disease.
  • Analyzed daily average prescribed outpatient morphine milligram equivalents and hospital visits.
  • Collected prescription information from the Georgia Prescription Drug Monitoring Program.
  • Found a significant positive correlation between average daily outpatient MME and emergency department visits.
  • Higher outpatient opioid doses were linked to increased hospital admissions and total days in the hospital.
  • Indicated that outpatient opioids may not prevent hospital visits and could increase medical needs.

Cite This Study

Elizabeth V. Minten (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d992https://doi.org/10.1182/blood-2025-2962
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis2025
  2. 2Temporal and agent-level trends in opioid prescribing for patients with severe sickle cell disease2026
  3. 3Opioid Dispensing Volume and Per-Patient Intensity in Sickle Cell Disease2026
  4. 4Opioid Timeliness in the Emergency Department and Hospitalizations for Acute Sickle Cell Pain2025 · 7 citations
  5. 5Investigating home‐based opioid use among youth with sickle cell disease using ecological momentary assessment2024 · 2 citations