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December 8, 2025BloodOpen Access

The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis

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Authors

SPSindhu C PokhriyalSASai Anusha AkellaTOThein Hlaing Oo

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Overview

Database review shows opioid use disorder worsens outcomes in sickle cell disease, increasing hospitalization and acute chest syndrome risk.

Key Points

  • Evaluate the association between opioid use disorder and healthcare outcomes in sickle cell disease.
  • Database analysis from National Inpatient Sample (2016-2021)
  • Identified hospitalized adult patients with sickle cell disease
  • Stratified patients based on comorbid opioid use disorder
  • Used multivariable logistic regression to assess inpatient outcomes
  • Analyzed total hospital charges and length of stay with linear regression.
  • 5.8% of sickle cell disease hospitalizations had opioid use disorder
  • No significant impact of opioid use disorder on inpatient mortality
  • Higher odds of acute chest syndrome in patients with opioid use disorder
  • Significant increase in total hospital charges associated with opioid use disorder
  • Longer length of stay in patients with opioid use disorder.

Cite This Study

Pokhriyal et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e49dhttps://doi.org/10.1182/blood-2025-1174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between outpatient opioid dosage and hospital visits in sickle cell disease patients2025
  2. 2Prevalence and factors associated with opioid use disorder among adolescents with sickle cell disease in Mulago hospital, Uganda2024 · 1 citations
  3. 3A national analysis of the impact of opioid use disorder on clinical outcomes in hospitalized patients with urothelial carcinoma.2026
  4. 4Impact of opioid use disorders on outcomes and readmission following cardiac operations2020 · 13 citations
  5. 5Determinants of Illness Severity and Mortality Risk Among Hospitalized Patients With Opioid Use Disorder: A National Analysis, 2015–20222026