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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a556 NCCT-Based Automatic Detection of Severe Ischemic Hypodensity in Posterior Brain Structures to Predict Poor Functional Outcome After Basilar Thrombectomy

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Authors

PCPere CanalsASAdrien ter SchiphorstNYNicole Yuen

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Overview

Retrospective cohort study shows hypodensity detection predicts worse outcomes in basilar artery occlusion patients, suggesting enhanced treatments are needed.

Key Points

  • To evaluate whether severe ischemic hypodensity on NCCT impacts outcomes for patients with basilar artery occlusion after EVT.
  • Retrospective multicenter cohort study of BAO patients treated with EVT
  • Used deep learning for segmentation of posterior brain structures on NCCT
  • Computed a hypodensity score to identify severe ischemic hypodensity in patients.
  • 19.3% of patients had severe ischemic hypodensity (SIH) and worse baseline NIHSS (p=0.029)
  • Odd ratio of 3.29 (95% CI 1.48-7.28, p=0.003) indicates SIH significantly associates with poorer mRS outcomes
  • Only 27.3% of SIH patients achieved good functional outcomes (mRS 0-3), compared to 53.6% without SIH (p=0.007).

Cite This Study

Canals et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f86bfa21ec5bbf08013https://doi.org/10.1093/esj/aakag023.343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ABSTRACT NUMBER: ESOC2026A217 HYPOPERFUSION INTENSITY RATIO MAY NOT BE A GOOD PREDICTOR OF FUNCTIONAL OUTCOME IN ANTERIOR CIRCULATION LARGE VESSEL OCCLUSION STROKE WHEN ADJUSTING FOR MULTIPLE COVARIATES2026
  2. 2Abstract A031: Non-Contrast CT Severe Hypodensity versus Net Water Uptake in Assessing Thrombectomy Treatment Effect in Large Core Stroke: <i>A Secondary Analysis of the SELECT2 Trial</i>2026
  3. 3ABSTRACT NUMBER: ESOC2026A423 HYPODENSITY DERIVED AUTOMATED NON-CONTRAST COMPUTED TOMOGRAPHY INFARCT CORE VOLUME PREDICTS POOR FUNCTIONAL OUTCOME2026
  4. 4Abstract DP364: Association of deep learning segmented ischemic core hypodensity on non-contrast CT with endovascular treatment benefit2026
  5. 5Accuracy of computed tomography perfusion-defined ischemic core and follow-up infarction after basilar artery thrombectomy2025