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May 8, 2026Reproduction Fertility and Development

FGF2, LIF, and IGF1 supplementation during in vitro maturation or culture improves equine ICSI embryo development in an age-dependent manner

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Authors

JSJoanne M. SmithPPPatricio D. PalaciosPFPablo Andrés Segura Forero

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Overview

Randomized trial examines age-dependent effects of FLI supplementation on equine embryo development.

Key Points

  • This study aims to evaluate the effects of FGF2, LIF, and IGF1 supplementation during maturation and culture of equine ICSI embryos, particularly in relation to the age of donor mares.
  • Oocytes assigned to in vitro maturation (IVM) with/without FLI supplementation.
  • Oocytes cultured post-ICSI using in vitro culture (IVC) media with/without FLI.
  • Developmental outcomes assessed across defined donor-mare age categories.
  • FLI supplementation did not affect maturation or cleavage rates.
  • Blastocyst formation significantly increased in oocytes from middle-aged mares with FLI during IVM/IVC.
  • Higher pregnancy establishment observed by Day 45 for FLI-treated embryos, especially after vitrification.

Cite This Study

Smith et al. (2026) studied this question.

synapsesocial.com/papers/69fd7f86bfa21ec5bbf0817fhttps://doi.org/10.1071/rd26023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Critical Functions of FGF2, LIF and IGF1 in the Improvement of In Vitro Embryo Production2026
  2. 2Cytokine-Supplemented Maturation Medium Enhances Cytoplasmic and Nuclear Maturation in Bovine Oocytes2024 · 2 citations
  3. 3Cytokine supplementation influences bovine embryo transcriptome during the preimplantation period2025 · 2 citations
  4. 4Impact of media supplements FGF2, LIF and IGF1 on the genome activity of porcine embryos produced in vitro2024 · 7 citations
  5. 5Insulin-like Growth Factor-1 Supplementation and Early Embryonic Developmental Competence of Immature Cattle Oocytes2025 · 1 citations