What question did this study set out to answer?

This study aims to evaluate the safety and effectiveness of bridging intravenous thrombolysis followed by endovascular treatment for M2 segment occlusions of the middle cerebral artery.

May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a1148 Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR Clean Registry Study

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Authors

MDMohamed DoheimUPMC Health System RKRobrecht KnapenUniversity Medical Center JSJulie StaalsDefense Information Systems Agency

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Implication

Randomized trial shows bridging therapy improves functional outcomes in MCA-M2 occlusions, indicating its potential benefit for certain patients.

Key Points

This study aims to evaluate the safety and effectiveness of bridging intravenous thrombolysis followed by endovascular treatment for M2 segment occlusions of the middle cerebral artery.
Included patients with MCA-M2 occlusions from the MR CLEAN Registry (March 2014-December 2018)
Primary outcomes assessed were modified Rankin Scale (mRS) scores at 90 days, with secondary outcomes including recanalization scores and symptomatic intracranial hemorrhage (sICH)
Analyses were conducted using multivariable methods and inverse probability treatment weighting.
IVT plus EVT showed reduced disability at 90 days (adjusted OR for mRS shift: 1.52; 95% CI: 1.04-2.21; p=0.03)
Mothership patients benefitted more from IVT+EVT (acOR for mRS shift: 1.79; 95% CI: 1.14-2.81; p=0.01), while no significant effect was observed in transfer group (acOR: 1.19; 95% CI: 0.60-2.34; p=0.62)
Functional outcomes favored IVT+EVT, with higher rates of mRS 0-1 (38.9% vs. 29.7%), mRS 0-2 (57.8% vs. 46.5%), and mRS 0-3 (73.2% vs. 59.4%).

Cite This Study

Doheim et al. (2026) studied this question.

synapsesocial.com/papers/69fd7fcdbfa21ec5bbf085f8 https://doi.org/10.1093/esj/aakag023.572

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Implication

Randomized trial shows bridging therapy improves functional outcomes in MCA-M2 occlusions, indicating its potential benefit for certain patients.

Abstract Number: Esoc2026a1148 Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR Clean Registry Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract Number: Esoc2026a1148 Direct Endovascular Versus Bridging Therapy in M2 Segment Occlusion of Middle Cerebral Artery: A MR Clean Registry Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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