What question did this study set out to answer?

To determine how elevated hematocrit levels influence thrombin generation, platelet dynamics, and thrombus formation following vascular injury.

March 1, 2017BloodOpen Access

Elevated hematocrit enhances platelet accumulation following vascular injury

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Authors

BWBethany L. WaltonUniversity of North Carolina at Chapel Hill MLMarcus LehmannColorado School of Mines TSTyler SkorczewskiUniversity of Wisconsin–Stout

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Implication

Experimental study demonstrates elevated hematocrit accelerates platelet deposition and thrombus growth under arterial flow, indicating red blood cells directly promote thrombosis.

Key Points

To determine how elevated hematocrit levels influence thrombin generation, platelet dynamics, and thrombus formation following vascular injury.
In vitro assays measuring thrombin generation across varying hematocrit levels in the presence and absence of platelets.
In silico direct numerical simulations modeling whole blood flow and interactions between platelets and thrombi.
Perfusion of human whole blood over collagen surfaces at arterial shear rates under elevated hematocrit conditions.
Elevating hematocrit increased thrombin generation in platelet-free systems in vitro, though this effect diminished in the presence of platelets.
Direct numerical simulations predicted that higher hematocrit increases both the frequency and duration of platelet-thrombus collisions.
Perfusion assays demonstrated that elevated hematocrit accelerated the rate of platelet deposition and overall thrombus growth at arterial shear rates.

Cite This Study

Walton et al. (2017) studied this question.

synapsesocial.com/papers/69fdad93f9b1bbfa2c2719ac https://doi.org/10.1182/blood-2016-10-746479

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Implication

Experimental study demonstrates elevated hematocrit accelerates platelet deposition and thrombus growth under arterial flow, indicating red blood cells directly promote thrombosis.

Elevated hematocrit enhances platelet accumulation following vascular injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Elevated hematocrit enhances platelet accumulation following vascular injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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