Why the study?
Does haematocrit influence primary haemostasis as measured by closure time in vitro?
Population
In vitro blood samples
Comparison
Systematic variation of haematocrit vs Different haematocrit levels
Design
Preclinical
Authors
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Haematocrit may offset thrombocytopenia effects on closure time in animals; leaves open whether normalization reduces human bleeding risk.
Does haematocrit influence primary haemostasis as measured by closure time in vitro?
Haematocrit inversely correlates with closure time in vitro, providing a pathophysiological rationale for normalizing haematocrit to reduce bleeding risk in thrombocytopenic and anaemic patients.
Eugster et al. (2005) studied this question.
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