Key result
Cardiopulmonary bypass significantly prolonged collagen/ADP closure times (203 vs 115 s; P=0.0001), which returned to near baseline after protamine, with a 96% negative predictive value for bleeding.
Why the study?
Does the PFA-100 platelet function analyzer accurately assess shear-mediated platelet dysfunction and predict post-operative bleeding in adult patients undergoing cardiac surgery?
Population
76 adult patients undergoing cardiac surgery
Comparison
Platelet function assessment using the PFA-100… vs Pre-operative baseline values
Design
Cohort
Follow-up
post-operative
Authors
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PFA-100 may identify low-bleeding-risk patients after bypass to avoid transfusions; leaves open whether routine use improves outcomes in randomized trials.
Observational (n=76)
Does the PFA-100 platelet function analyzer accurately assess shear-mediated platelet dysfunction and predict post-operative bleeding in adult patients undergoing cardiac surgery?
Absolute Event Rate: 203% vs 115%
p-value: p=0.0001
The PFA-100 analyzer demonstrates reversible shear-mediated platelet dysfunction during cardiopulmonary bypass and has a high negative predictive value (96%) for post-operative bleeding, potentially identifying patients who do not need platelet transfusions.
Slaughter et al. (2001) conducted an observational in Cardiac surgery (n=76). Cardiopulmonary bypass (CPB) vs. Pre-operative baseline was evaluated on Collagen/ADP closure times (p=0.0001). Cardiopulmonary bypass significantly prolonged collagen/ADP closure times (203 vs 115 s; P=0.0001), which returned to near baseline after protamine, with a 96% negative predictive value for bleeding.
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