Key result
Preoperative prolongation of closure time on the PFA-200 COL/EPI test was marginally associated with an increased risk of intraoperative bleeding (HR 1.55) and significantly increased postoperative red blood cell transfusion.
Why the study?
Use of PFA-100/200 for assessing platelet function instead of bleeding time is increasing, but its role in predicting perioperative bleeding risk remains controversial.
Does preoperative PFA-200 testing predict the risk of perioperative bleeding in patients undergoing surgery under general anesthesia?
Population
703 patients who underwent surgery under general anesthesia
Comparison
Prolonged vs normal preoperative PFA-200 results
Design
Retrospective study
Authors
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Preoperative PFA-200 results should not yet guide transfusion decisions; leaves open its incremental value beyond clinical factors in prospective studies.
Cohort (n=703)
No
Does preoperative PFA-200 testing predict the risk of perioperative bleeding in patients undergoing surgery under general anesthesia?
Hazard Ratio: 1.55 (95% CI 0.97–2.47)
Absolute Event Rate: 20.1% vs 14.3%
p-value: p=0.068
Preoperative PFA-200 testing may help predict perioperative bleeding risk and transfusion needs, though results are influenced by multiple clinical factors.
Yu et al. (2020) conducted a cohort in Perioperative bleeding risk (n=703). Prolonged closure time on PFA-200 COL/EPI test vs. Normal closure time on PFA-200 COL/EPI test was evaluated on Intraoperative bleeding over 300 mL (HR 1.55, 95% CI 0.97-2.47, p=0.068). Preoperative prolongation of closure time on the PFA-200 COL/EPI test was marginally associated with an increased risk of intraoperative bleeding (HR 1.55) and significantly increased postoperative red blood cell transfusion.
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