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January 1, 1975Journal of Clinical InvestigationOpen Access

Regional myocardial blood flow during graded treadmill exercise in the dog.

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Authors

RBR M BallUnited States Department of Veterans AffairsRBR J BacheUniversity of Minnesota Medical CenterFCF R CobbUniversity of Minnesota

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Implication

Randomized trial measures myocardial blood flow changes with exercise in dogs, suggesting exercise balances heart muscle flow.

Key Points

  • To measure regional myocardial blood flow in dogs at rest and during varied exercise intensities.
  • Measured blood flow using radioactive microspheres in nine dogs during rest and three exercise levels.
  • Heart rates increased in a controlled manner from 152 to 240 beats/min during exercise.
  • Assessed both left and right ventricular blood flow and endo/epi ratios.
  • Mean left ventricular myocardial flow increased from 0.94 to 3.90 ml/min/g with exercise as heart rate rose (R=0.87).
  • Endocardial flow ratios at rest averaged 1.12-1.33 but equaled 1.00 during exercise, indicating balanced perfusion.
  • Right ventricular flows also increased linearly with heart rate and showed no difference between endo/epi ratios throughout.

Cite This Study

Ball et al. (1975) studied this question.

synapsesocial.com/papers/69fe79a8d8476229fea3597ehttps://doi.org/10.1172/jci107916
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Exercise on Cardiac Output, Left Coronary Flow and Myocardial Metabolism in the Unanesthetized Dog1965 · 231 citations
  2. 2Distribution of the Coronary Blood Flow across the Canine Heart Wall during Systole1974 · 144 citations
  3. 3Cardiovascular Performance of Alaska Sled Dogs during Exercise1969 · 151 citations
  4. 4Effect of Ischemia and Antianginal Drugs on the Distribution of Radioactive Microspheres in the Canine Left Ventricle1971 · 375 citations
  5. 5Nonuniform distribution of blood flow and gradients of oxygen tension within the heart1964 · 251 citations