Why the study?
Does ETA receptor blockade improve NO-mediated endothelial function and inhibit atherosclerosis in apolipoprotein E-deficient mice?
Does ETA receptor blockade improve NO-mediated endothelial function and inhibit atherosclerosis in apolipoprotein E-deficient mice?
Chronic ETA receptor blockade normalizes NO-mediated endothelial dysfunction and reduces atheroma formation independent of plasma cholesterol and blood pressure in a mouse model of atherosclerosis.
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May support ETA blockade in atherosclerosis models; leaves open human translation and clinical trials.
Barton et al. (1998) studied this question.
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