What question did this study set out to answer?

This research aims to evaluate the effectiveness of the 10 × Genomics Flex Gene Expression protocol for profiling xenograft samples.

May 9, 2026Genome biologyOpen Access

10 × Genomics Flex Gene Expression is a powerful tool for single-cell transcriptomics of xenografts models

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Randomized trial demonstrates gene expression profiling in xenografts, highlighting a new analysis tool.

This research aims to evaluate the effectiveness of the 10 × Genomics Flex Gene Expression protocol for profiling xenograft samples.
Utilized a probe-based approach for gene expression profiling of mixed human-mouse xenograft samples.
Combined human and mouse probe sets in a single reaction to enhance profiling accuracy.
Handled sample materials through fixed and frozen protocols before scRNA-seq analysis.
Achieved significant improvement in species-specific count tables, outperforming cross-reactive probes.
Implemented a method to effectively remove cross-reactive signals, resulting in cleaner gene expression matrices.
Supported thorough analysis of both the xenograft and the surrounding microenvironment without the need for flow sorting.

Llorà-Batlle et al. (2026) studied this question.

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