Why the study?
It remained unclear whether minocycline's beneficial effects in hypertension stem primarily from its anti-inflammatory or antimicrobial actions.
Does central administration of CMT-3 reduce mean arterial pressure and gut pathology in hypertensive rat models?
Population
Ang II-infused hypertensive rats and spontaneously hypertensive rats (SHR)
Comparison
Intracerebroventricular CMT-3 infusion vs control
Design
Animal experimental study
Authors
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Central microglial inhibition may target brain-gut axis in hypertension; hypothesis-generating and requires human translation before any clinical consideration.
Does central administration of CMT-3 reduce mean arterial pressure and gut pathology in hypertensive rat models?
Central inhibition of microglial activation with CMT-3 attenuates hypertension and restores gut microbiota in rat models, highlighting a brain-gut axis in hypertension.
Sharma et al. (2019) studied this question.
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