Key result
Two-kidney, one-clip surgery significantly elevated sympathetic nerve activity in both hypertensive (47.7 μV) and normotensive (32.8 μV) rats compared to sham (20.5 μV, P<0.05) at 3 weeks.
Population
22 male Wistar rats in a decorticated in situ working heart-brainstem preparation
Comparison
Two-kidney, one-clip Goldblatt model evaluated… vs Sham-operated animals
Design
Preclinical
Follow-up
3 weeks
Authors
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Early SNA rise in 2K1C rats is hypothesis-generating; leaves open translation to human renovascular hypertension.
p-value: p=<0.05
In the 2K1C rat model, sympathetic nerve activity is elevated prior to the onset of hypertension, driven partly by enhanced respiratory modulation.
Oliveira‐Sales et al. (2015) studied Renovascular hypertension (n=22). Two-kidney, one-clip (2K1C) surgery vs. Sham operation was evaluated on Sympathetic nerve activity (SNA) (p=<0.05). Two-kidney, one-clip surgery significantly elevated sympathetic nerve activity in both hypertensive (47.7 μV) and normotensive (32.8 μV) rats compared to sham (20.5 μV, P<0.05) at 3 weeks.
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