Key result
Renovascular hypertension in sheep increases cardiac sympathetic bursts by ~56% while decreasing renal bursts.
Why the study?
Does unilateral renal artery clipping alter cardiac and renal sympathetic nerve activity and baroreflex control in adult ewes?
Does unilateral renal artery clipping alter cardiac and renal sympathetic nerve activity and baroreflex control in adult ewes?
Absolute Event Rate: 39% vs 25%
p-value: p=<0.05
Renovascular hypertension in a sheep model is associated with a preferential early increase in cardiac sympathetic nerve activity and a decrease in contralateral renal sympathetic nerve activity.
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Suggests cardiac sympathetic targeting merits exploration in hypertension; leaves open human translation from this animal model.
Tromp et al. (2018) studied Renovascular Hypertension (n=27). Unilateral renal artery clipping vs. Sham surgery was evaluated on Cardiac sympathetic burst incidence (bursts/100 beats) (p=<0.05). Renovascular hypertension induced by unilateral renal artery clipping in sheep significantly increased cardiac sympathetic burst incidence (39 vs 25 bursts/100 beats) and decreased renal sympathetic burst incidence.
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