June 1, 2002Journal of Hypertension
Increased cardiac sympathetic drive in renovascular hypertension
Key result
Renovascular hypertension was associated with a 127% increase in cardiac noradrenaline spillover compared with healthy controls (200 vs 88 pmol/min, P<0.05).
Why the study?
Is cardiac sympathetic activity increased in patients with hypertension and renal artery stenosis compared to healthy subjects?
Population
14 patients with hypertension and angiographically identified renal artery stenosis and 19 healthy subjects.
Comparison
Measurement of cardiac and total body… vs 19 healthy subjects.
Design
Case-control
Authors
Discussion
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Implication
Suggests cardiac sympathetic overdrive in renovascular hypertension; hypothesis-generating and should not alter practice without further evidence.
Study Design
Type
Observational (n=33)
Structured PICO
Is cardiac sympathetic activity increased in patients with hypertension and renal artery stenosis compared to healthy subjects?
P
Population
33 subjects, including 14 patients with hypertension and renal artery stenosis and 19 healthy controls, assessed for cardiac sympathetic activity.
E
Exposure
Measurement of cardiac and total body noradrenaline spillover using right heart catheterization and radiotracer dilution technique with infusion of tritiated noradrenaline and adrenaline.
C
Comparator
19 healthy subjects.
O
Outcome
Cardiac noradrenaline (NA) spillover as an index of cardiac sympathetic nervous activity.surrogate
Main Result
Absolute Event Rate: 200% vs 88%
p-value: p=< 0.05
Cite This Study
Petersson et al. (2002) conducted an observational in Renovascular hypertension (n=33). Renovascular hypertension vs. Healthy subjects was evaluated on Cardiac NA spillover (p=< 0.05). Renovascular hypertension was associated with a 127% increase in cardiac noradrenaline spillover compared with healthy controls (200 vs 88 pmol/min, P<0.05).