Key result
Hypertensive patients with renal parenchymal disease had significantly higher muscle sympathetic nerve activity compared to matched controls (31 vs 18 bursts/min; P<0.01).
Population
57 hypertensive patients with renal parenchymal disease, age range 18 to 62, creatinine clearance 10 to 114…
Design
Cross-sectional
Authors
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Supports elevated sympathetic activity in renal parenchymal hypertension; leaves open independence from nephron number and therapeutic targeting.
Case-Control
Absolute Event Rate: 31% vs 18%
p-value: p=<0.01
Sympathetic nerve activity is inappropriately elevated in hypertensive patients with chronic renal disease relative to their volume status, and this overactivity is not solely due to a reduced nephron mass.
Klein et al. (2003) conducted a case-control in Chronic Renal Disease and Hypertension. Renal parenchymal disease vs. Matched control subjects was evaluated on Muscle sympathetic nerve activity (MSNA) (p=<0.01). Hypertensive patients with renal parenchymal disease had significantly higher muscle sympathetic nerve activity compared to matched controls (31 vs 18 bursts/min; P<0.01).
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