Key result
Renovascular hypertension was associated with a 100% increase in total body norepinephrine spillover and a 60% increase in muscle sympathetic nerve activity compared with healthy subjects (P<0.01).
Why the study?
Does renovascular hypertension associate with increased total and regional sympathetic nerve activity compared to healthy subjects?
Population
65 patients with renovascular hypertension and 15 age-matched healthy subjects.
Design
Case-control
Authors
Loading...
Sympathetic overactivity may contribute to renovascular hypertension; extends SNS observations but leaves open therapeutic targeting.
Observational (n=80)
Does renovascular hypertension associate with increased total and regional sympathetic nerve activity compared to healthy subjects?
p-value: p=<0.01
Renovascular hypertension is associated with significantly elevated sympathetic nerve activity, potentially contributing to disease progression and cardiovascular risk.
Johansson et al. (1999) conducted an observational in Renovascular hypertension (n=80). Renovascular hypertension vs. Healthy subjects was evaluated on Total body norepinephrine (NE) spillover and muscle sympathetic nerve activity (MSNA) (p=<0.01). Renovascular hypertension was associated with a 100% increase in total body norepinephrine spillover and a 60% increase in muscle sympathetic nerve activity compared with healthy subjects (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: