Key result
His bundle pacing is linked to ~29% fewer composite events versus RVP.
Why the study?
Right ventricular pacing is associated with heart failure and increased mortality, and His bundle pacing is a physiological alternative whose clinical outcomes need evaluation.
Does His bundle pacing reduce the composite of death, heart failure hospitalization, or upgrade to biventricular pacing compared to right ventricular pacing in patients requiring initial pacemaker implantation?
Comparison
Permanent His bundle pacing vs right ventricular pacing
Design
Observational cohort study at two hospitals
Authors
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His bundle pacing is a feasible and safe alternative to right ventricular pacing that significantly reduces the combined risk of death, heart failure hospitalization, and need for biventricular pacing upgrade.
Cohort (n=765)
Yes
Does His bundle pacing reduce the composite of death, heart failure hospitalization, or upgrade to biventricular pacing compared to right ventricular pacing in patients requiring initial pacemaker implantation?
Hazard Ratio: 0.71 (95% CI 0.534–0.944)
Absolute Event Rate: 25% vs 32%
p-value: p=0.02
His bundle pacing is a feasible and safe alternative to right ventricular pacing that significantly reduces the combined risk of death, heart failure hospitalization, and need for biventricular pacing upgrade.
Abdelrahman et al. (2018) conducted a cohort in requiring initial pacemaker implantation (n=765). His bundle pacing (HBP) vs. Right ventricular pacing (RVP) was evaluated on combined endpoint of death, HFH, or upgrade to BiVP (HR 0.71, 95% CI 0.534-0.944, p=0.02). His bundle pacing reduced the combined endpoint of death, heart failure hospitalization, or upgrade to biventricular pacing compared to right ventricular pacing (HR 0.71; 95% CI 0.534-0.944; p=0.02).
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