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December 13, 2005American Journal of Medical Genetics Part AOpen Access

Echocardiographic findings in classical and hypermobile Ehlers–Danlos syndromes

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Why the study?

What are the structural cardiovascular alterations detectable by two-dimensional echocardiography in patients with classical and hypermobile Ehlers-Danlos syndromes?

Population

38 patients with hypermobile and classical Ehlers-Danlos syndromes, including 7 males and 31 females, with…

Design

Cross-sectional

Authors

NMNazli B. McDonnellInstitute on AgingBGBeverly GormanNational Institutes of HealthKMKatherine W. MandelNational Institutes of Health

Discussion

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Implication

Echocardiography may identify alterations in classical/hyper mobile EDS; hypothesis-generating and should not yet change practice.

Structured PICO

What are the structural cardiovascular alterations detectable by two-dimensional echocardiography in patients with classical and hypermobile Ehlers-Danlos syndromes?

P
Population
38 patients with hypermobile and classical Ehlers-Danlos syndromes (EDS), including 7 males and 31 females, with an age range from 12-60 years.
I
Intervention
Two-dimensional echocardiography
O
Outcome
Structural cardiovascular alterationssurrogate

Two-dimensional echocardiography reveals frequent structural cardiovascular alterations, such as a prominent right coronary artery and abnormal pouching of the sinuses of Valsalva, in patients with classical and hypermobile Ehlers-Danlos syndromes.

Cite This Study

McDonnell et al. (2005) studied this question.

synapsesocial.com/papers/69ff8e2f2ff633f365779521https://doi.org/10.1002/ajmg.a.31035

Topics

EchocardiographyValvular heart disease
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Also Consider

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  1. 1Reliability of echocardiographic assessment of left ventricular structure and function1999 · 303 citations
  2. 2Congestive Heart Failure With Normal Left Ventricular Systolic Function1996 · 133 citations
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  5. 5The Spectrum of Cardiac Defects in the Ehlers-Danlos Syndrome, Types I and III1980 · 163 citations