What question did this study set out to answer?

To provide an updated comprehensive collection of protein multiple sequence alignments and profile hidden Markov models for genome annotation.

January 1, 2000Nucleic Acids ResearchOpen Access

The Pfam Protein Families Database

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To provide an updated comprehensive collection of protein multiple sequence alignments and profile hidden Markov models for genome annotation.
Generated profile hidden Markov models and multiple sequence alignments for 1,815 protein families in version 4.3.
Integrated the Wise2 software package to enable direct searches of genomic DNA sequences against the database.
Pfam family models matched 63% of proteins cataloged in SWISS-PROT 37 and TrEMBL 9.
Coverage analysis identified matches for up to 50% of proteins encoded in complete genomes.

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Implication

Database analysis demonstrates extensive protein family coverage across sequenced genomes, highlighting hidden Markov models for automated genomic annotation.

Cite This Study

Alex Bateman (2000) studied this question.

synapsesocial.com/papers/69ffa98e2ff633f36577a3be https://doi.org/10.1093/nar/28.1.263

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Implication

Database analysis demonstrates extensive protein family coverage across sequenced genomes, highlighting hidden Markov models for automated genomic annotation.

The Pfam Protein Families Database

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Implication

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The Pfam Protein Families Database

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Implication

Cite This Study

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