What question did this study set out to answer?

This study evaluates the impact of cognitive impairment on work productivity and health-related quality of life in individuals with narcolepsy and idiopathic hypersomnia.

May 10, 2026SLEEP

0698 Real-World Experience and Impact of Cognitive Impairment in Narcolepsy and Idiopathic Hypersomnia: Survey Results from the ASPIRE Study

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Authors

MDMichael DoaneAlkermes (Ireland)JTJoanne TuckerIQVIA (United Kingdom)KMKristen McCauslandIQVIA (United Kingdom)

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Implication

Survey reveals cognitive impairment affects work productivity and quality of life in narcolepsy and IH, suggesting significant unmet needs.

Key Points

This study evaluates the impact of cognitive impairment on work productivity and health-related quality of life in individuals with narcolepsy and idiopathic hypersomnia.
Conducted an online survey of 366 US adults diagnosed with narcolepsy type 1, narcolepsy type 2, or idiopathic hypersomnia.
Participants completed the BC-CCI-E to assess cognitive impairment, as well as questionnaires on work productivity and health-related quality of life.
Analyzed subgroup differences based on severity of cognitive impairment.
89% of participants reported mild-to-severe cognitive impairment, adversely affecting work and daily activities.
Participants with significant cognitive impairment had lower health-related quality of life scores (EQ-5D-5L: mean 0.61 vs 0.85, p<0.001).
Cognitive impairment led to greater activity impairment (65% vs 41%, p<0.001) and work impairment (58% vs 25%, p<0.001) compared to those with minimal impairment.

Cite This Study

Doane et al. (2026) studied this question.

synapsesocial.com/papers/6a00217ac8f74e3340f9c5f8 https://doi.org/10.1093/sleep/zsag091.0697

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Implication

Survey reveals cognitive impairment affects work productivity and quality of life in narcolepsy and IH, suggesting significant unmet needs.

0698 Real-World Experience and Impact of Cognitive Impairment in Narcolepsy and Idiopathic Hypersomnia: Survey Results from the ASPIRE Study

Discussion

Member takes

Implication

Key Points

Cite This Study

0698 Real-World Experience and Impact of Cognitive Impairment in Narcolepsy and Idiopathic Hypersomnia: Survey Results from the ASPIRE Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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