Survey reveals fatigue significantly affects health-related quality of life and work productivity in narcolepsy and idiopathic hypersomnia.
Key Points
This study evaluates the impact of fatigue on work productivity and health-related quality of life in individuals with narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia.
Conducted an online survey of 366 adults diagnosed with narcolepsy or idiopathic hypersomnia.
Measured fatigue severity using the PROMIS-Fatigue Short-Form 6a and assessed HRQoL with EQ-5D-5L and EQ-VAS.
Analyzed work and activity impairment through the Work Productivity and Activity Impairment Questionnaire.
91% reported mild-to-severe fatigue, with greater activity impairment (66% vs 28%; p<0.001) and work impairment (59% vs 21%; p<0.001) compared to those with normal fatigue.
Mean HRQoL scores were significantly lower for participants with mild-to-severe fatigue (EQ-5D-5L: 0.61 vs 0.88 [p<0.001]; EQ-VAS: 58 vs 78 [p<0.001]).
Findings were consistent across narcolepsy type 1, type 2, and idiopathic hypersomnia populations.