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June 1, 2002HypertensionOpen Access

Endothelial removal or nitric oxide synthase inhibition increased mean superoxide release with a corresponding reduction in peroxynitrite formation, whereas NO donors and superoxide scavengers reduced superoxide release.

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Why the study?

How do nitric oxide and superoxide interact to modulate peroxynitrite formation in human blood vessels?

Population

Human internal mammary arteries, radial arteries, and saphenous veins from 78 patients undergoing coronary…

Comparison

Endothelial removal, nitric oxide synthase… vs Basal state / intact endothelium

Design

Preclinical

Authors

TGTomasz J. GuzikNWNick E.J. WestRPRavi Pillai

Discussion

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Overview

Does not support clinical changes in hypertension; leaves open translation of NO-superoxide interactions to human vessels.

Structured PICO

How do nitric oxide and superoxide interact to modulate peroxynitrite formation in human blood vessels?

P
Population
Human internal mammary arteries, radial arteries, and saphenous veins from 78 patients undergoing coronary bypass surgery
I
Intervention
Endothelial removal, nitric oxide synthase inhibition, NO donors, and superoxide scavengers
C
Comparator
Basal state / intact endothelium
O
Outcome
Production of NO, superoxide, and peroxynitritesurrogate

This study provides direct evidence for coordinated vascular signaling mediated by interactions between NO, superoxide, and peroxynitrite in human blood vessels.

Cite This Study

Guzik et al. (2002) studied this question.

synapsesocial.com/papers/6a006933831589f3542dd0dchttps://doi.org/10.1161/01.hyp.0000018041.48432.b5
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