Why the study?
Does TNF-alpha deficiency prevent acute myocardial rupture and chronic left ventricular dysfunction after myocardial infarction in mice?
Population
TNF knockout (TNF-/-) mice (n=80) and C57/BL wild-type (WT) mice (n=120)
Comparison
Left anterior descending ligation vs Sham operation; Wild-type mice compared to…
Design
Preclinical, Animals were randomized to left anterior descending ligation or…
Follow-up
28 days
Authors
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TNF-α may drive post-MI rupture; animal data leave open whether inhibition improves human outcomes.
Does TNF-alpha deficiency prevent acute myocardial rupture and chronic left ventricular dysfunction after myocardial infarction in mice?
Elevated local TNF-alpha in the infarcted myocardium contributes to acute myocardial rupture and chronic left ventricle dysfunction by inducing inflammation, matrix degradation, and apoptosis.
Sun et al. (2004) studied this question.