Why the study?
Does eplerenone prevent obesity-induced hypertension and glomerular hyperfiltration in dogs fed a high-fat diet?
Population
Chronically instrumented dogs (n=13)
Comparison
Eplerenone 10 mg/kg twice daily, started 10 days… vs Untreated control dogs fed a high-fat diet for 5…
Design
Preclinical
Follow-up
5 weeks
Authors
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May attenuate obesity-induced hypertension in dogs; leaves open translation to human obesity-related hypertension.
Does eplerenone prevent obesity-induced hypertension and glomerular hyperfiltration in dogs fed a high-fat diet?
Eplerenone markedly attenuates glomerular hyperfiltration, sodium retention, and hypertension associated with chronic dietary-induced obesity in dogs, indicating aldosterone's role in obesity-related hypertension.
Paula et al. (2003) studied this question.
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