Why the study?
Does lisinopril reduce blood pressure more effectively or safely than hydrochlorothiazide or placebo in obese hypertensive patients?
Population
232 obese patients with hypertension (office diastolic pressure between 90 and 109 mm Hg)
Comparison
Lisinopril (10, 20, or 40 mg daily) for 12 weeks vs Hydrochlorothiazide or placebo for 12 weeks
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
Loading...
Both lower BP effectively in obese hypertension; confirms comparable efficacy while favoring lisinopril to avoid metabolic effects.
Does lisinopril reduce blood pressure more effectively or safely than hydrochlorothiazide or placebo in obese hypertensive patients?
Lisinopril and hydrochlorothiazide are equally effective at lowering blood pressure in obese hypertensive patients, but lisinopril avoids the adverse metabolic effects on glucose and potassium seen with hydrochlorothiazide.
Reisin et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: