Why the study?
Does lisinopril or hydrochlorothiazide reduce ambulatory blood pressure in obese hypertensive patients?
Population
124 obese hypertensive patients
Comparison
Lisinopril or hydrochlorothiazide vs Placebo
Design
RCT, Randomized to three groups
Follow-up
12 weeks
Authors
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Supports lisinopril or HCTZ as initial therapy in obese hypertension; extends RCT evidence to ambulatory BP monitoring.
Does lisinopril or hydrochlorothiazide reduce ambulatory blood pressure in obese hypertensive patients?
In obese hypertensive patients, both lisinopril and hydrochlorothiazide effectively lower ambulatory blood pressure, with treatment response influenced by sex, race, and nocturnal dipping status.
REISIN et al. (1998) studied this question.
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