Key result
Oral captopril significantly lowered mean arterial pressure, plasma norepinephrine, fasting glucose, and cholesterol levels in a dog model of obesity-induced hypertension.
Why the study?
Does oral captopril improve blood pressure, metabolic parameters, and vascular histology in a dog model of obesity-induced hypertension?
Population
10 age-matched beagle dogs on a high-fat diet (model of obesity-induced hypertension)
Comparison
Oral captopril vs No captopril treatment (high-fat diet only)
Design
Preclinical
Follow-up
12 weeks
Authors
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Does not support clinical use in obesity hypertension; leaves open translation of metabolic benefits from canine models.
Does oral captopril improve blood pressure, metabolic parameters, and vascular histology in a dog model of obesity-induced hypertension?
In a canine model of obesity-induced hypertension, captopril improved blood pressure, metabolic parameters, and early atherosclerotic changes.
Robles et al. (1993) studied Obesity-induced hypertension (n=10). Oral captopril vs. No captopril treatment was evaluated on Mean arterial pressure, plasma norepinephrine, fasting glucose, and cholesterol levels. Oral captopril significantly lowered mean arterial pressure, plasma norepinephrine, fasting glucose, and cholesterol levels in a dog model of obesity-induced hypertension.
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