Fetal and infant origins of cardiovascular disease.

David J. Barker; Caroline Fall

doi:10.1136/adc.68.6.797

June 1, 1993Archives of Disease in ChildhoodOpen Access

Fetal and infant origins of cardiovascular disease.

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Key Points

To examine whether intrauterine growth retardation and lower infant weight are associated with persistent metabolic changes and increased cardiovascular mortality in adult life.
Historical cohort analysis of 1,586 men born in Sheffield between 1907 and 1924, assessing birth weight, head circumference, and ponderal index against adult mortality.
Cohort evaluation of men born in Hertfordshire between 1911 and 1930, measuring associations between birth weight, weight at one year of age, and adult cardiovascular death.
Coronary heart disease and stroke mortality in the Sheffield cohort fell progressively across increasing birth weights, head circumferences, and ponderal indices.
In the Hertfordshire cohort, men weighing 8.2 kg (18 lbs) or less at one year had a threefold greater coronary disease death rate than men weighing 12.3 kg (27 lbs) or more.

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Implication

Cohort studies demonstrate increased cardiovascular mortality in men with lower infant weights, suggesting early developmental origins of adult disease.

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Barker et al. (1993) studied this question.

synapsesocial.com/papers/6a00b9c1831589f3542de537 https://doi.org/10.1136/adc.68.6.797

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Fetal and infant origins of cardiovascular disease.

Key Points

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Implication

Abstract

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Cite This Study

Fetal and infant origins of cardiovascular disease.

Key Points

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Implication

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