What question did this study set out to answer?

Identify clinical and angiographic factors associated with subsequent ischemic stroke in the territory of a stenotic intracranial artery to target high-risk patients for future interventional trials.

January 24, 2006Circulation

Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis

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Authors

SKScott E. KasnerTulane University MCMarc I. ChimowitzRutgers, The State University of New Jersey MLMichael LynnCornell University

Discussion

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Implication

Randomized double-blind trial reveals severe stenosis and recent symptoms increase recurrent stroke risk in symptomatic intracranial stenosis, highlighting high-risk candidates for stenting.

Key Points

Identify clinical and angiographic factors associated with subsequent ischemic stroke in the territory of a stenotic intracranial artery to target high-risk patients for future interventional trials.
Conducted a secondary analysis of the randomized, double-blinded, multicenter WASID trial involving 569 patients with transient ischemic attack or stroke due to 50% to 99% intracranial artery stenosis.
Evaluated patients over a mean follow-up of 1.8 years (median time to randomization was 17 days) using multivariable Cox proportional hazards models.
Subsequent ischemic stroke occurred in 106 patients (19.0%), with 77 (73%) occurring within the territory of the stenotic artery.
Risk of stroke in the stenotic territory was highest with severe stenosis ≥70% (hazard ratio 2.03; 95% confidence interval 1.29 to 3.22; P=0.0025) and enrollment ≤17 days from qualifying event (hazard ratio 1.69; 95% confidence interval 1.06 to 2.72; P=0.028).
Female sex had a borderline association with higher stroke risk (hazard ratio 1.59; 95% confidence interval 1.00 to 2.55; P=0.051), whereas stenosis location, event type, and prior antithrombotic use showed no association.

Cite This Study

Kasner et al. (2006) studied this question.

synapsesocial.com/papers/6a00ddccb124fe5819861918 https://doi.org/10.1161/circulationaha.105.578229

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Implication

Randomized double-blind trial reveals severe stenosis and recent symptoms increase recurrent stroke risk in symptomatic intracranial stenosis, highlighting high-risk candidates for stenting.

Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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