Why the study?
Treatment of mitral regurgitation associated with severe mitral annular calcification is challenging due to the high risk of fatal atrioventricular groove disruption and significant paravalvular leak.
Does transcatheter mitral valve replacement with the Tendyne valve improve clinical outcomes in patients with mitral regurgitation and severe mitral annular calcification?
Does transcatheter mitral valve replacement with the Tendyne valve improve clinical outcomes in patients with mitral regurgitation and severe mitral annular calcification?
TMVR with the Tendyne system is feasible and effectively eliminates mitral regurgitation in patients with severe MAC, though 1-year mortality remains high (40%) in this challenging population.
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High mortality signals caution against routine Tendyne use in severe MAC; leaves open survival benefit versus medical therapy in prospective trials.
Gössl et al. (2022) studied this question.
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