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May 11, 2026Nature CommunicationsOpen Access

Synthesis of sialylated human milk oligosaccharides by automated glycan assembly

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Authors

YKYan‐Ting KuoKHKim Le Mai HoangPSPeter H. Seeberger

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Overview

Randomized trial demonstrates effective synthesis of sialylated glycans, highlighting advancements in oligosaccharide production.

Key Points

  • This research addresses the challenges in synthesizing sialylated glycans efficiently using automated methods.
  • Utilized automated glycan assembly (AGA) with macrobicyclic sialic acid building blocks.
  • Developed a reliable protocol for α(2,3)- and α(2,6)-sialylation on solid support.
  • Assembled nine sialylated human milk oligosaccharides for testing.
  • Successfully synthesized nine sialylated HMOs including fucosyldisialyllacto-N-tetraose (DSLNF II).
  • Achieved pure, functionalized complex glycans ready for biological applications.
  • Improved deprotection protocol enhances access to sialylated glycans for future research.

Cite This Study

Kuo et al. (2026) studied this question.

synapsesocial.com/papers/6a0172ac3a9f334c28272d22https://doi.org/10.1038/s41467-026-73028-w
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