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December 5, 2025Nature CommunicationsOpen Access

p-nitrobenzyloxycarbonyl protective group as key to automated glycan assembly of neutral human milk oligosaccharides

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Authors

MLMei‐Huei LinYKYan‐Ting KuoKHKim L. Hoang

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Overview

This analysis demonstrates enhanced coupling efficiency in chemical synthesis of human milk oligosaccharides, suggesting robustness of the approach.

Key Points

  • Chemical synthesis of homogeneous HMOs improved with glucosamine modification, enhancing overall yield.
  • Robustness of p-nitrobenzyloxycarbonyl protecting group ensures efficient assembly of diverse oligosaccharide structures.
  • Automated glycan assembly allows significant advances in the purity of human milk oligosaccharides.
  • Extensive deprotection pathways provide versatility for further oligosaccharide synthesis endeavors.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/694022612d562116f28fc93fhttps://doi.org/10.1038/s41467-025-66557-3
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