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February 27, 2026

Modular Click Assembly of Trivalent Scaffolds Displaying Homogeneous and Mixed Human Milk Oligosaccharide Motifs.

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Authors

YLYing-Jia LiuKOKai-Eng OoiCKCheng-Yu Kuo

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Overview

This research demonstrates a glycomimetic platform that creates diverse HMO displays in a single step, suggesting potential in glycan-protein interactions.

Key Points

  • The aim is to develop a platform for assembling human milk oligosaccharides to investigate their structural and functional properties.
  • Introduced a tri-alkyne core for the assembly of trivalent HMO displays.
  • Used copper-catalyzed azide-alkyne cycloaddition to attach azido-functionalized HMOs.
  • Offered control over display density and composition of oligosaccharides.
  • Produced mono-, di-, and tri-substituted conjugates effectively in a single step.
  • Revealed steric effects that cap trisubstitution based on substitution patterns.
  • Enabled both homogeneous and mixed HMO presentations for further glycan-protein recognition studies.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69a13571ed1d949a99abf501https://doi.org/10.1002/asia.70650
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Also Consider

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  1. 1Regioselective Enzymatic Galactosylation Enabled Divergent Synthesis of Asymmetrical Biantennary Human Milk Oligosaccharides2024 · 11 citations
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  4. 4Rapid Access to Human Milk Oligosaccharide Analogues through a Partially Protected <i>N</i> -Acetylglucosamine Donor2026 · 1 citations
  5. 5Synthesis of sialylated human milk oligosaccharides by automated glycan assembly2026