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May 11, 2026Journal of the American College of Cardiology334 citations

Eosinophilic Myocarditis

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MBMichela BrambattiHeart Failure & TransplantMMMaria Vittoria MatassiniOspedali Riuniti di AnconaEAEric AdlerHeart Failure & Transplant

Key Points

  • To review the pathophysiological mechanisms, clinical manifestations, diagnostic evaluation, and therapeutic strategies associated with eosinophilic myocarditis.
  • Review of clinical presentations, laboratory markers, and cardiac imaging modalities including echocardiography and cardiac magnetic resonance.
  • Evaluation of histological criteria via endomyocardial biopsy and analysis of underlying systemic etiologies.
  • Eosinophilic infiltration into myocardial tissue triggers cytokine release, microvascular thrombosis, necrosis, and progressive endocardial fibrosis.
  • Early recognition and prompt initiation of corticosteroid or targeted immunosuppressive therapy significantly reduce adverse cardiac events and reverse myocardial injury.
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Cite This Study

Brambatti et al. (2017) studied this question.

synapsesocial.com/papers/6a019f05c802e0b13c07fa5ehttps://doi.org/10.1016/j.jacc.2017.09.023
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