Key result
Steroid therapy resolves acute necrotizing eosinophilic myocarditis despite an initial LVEF of ~19%.
Why the study?
The necrotizing phase of eosinophilic myocarditis is often fulminant and rapidly fatal, predominantly in males, but cases in young females without known cause are rare.
Case Report (n=1)
Steroid therapy can lead to prompt resolution of severe acute necrotizing eosinophilic myocarditis.
May support steroids in acute eosinophilic myocarditis with severe LV dysfunction; hypothesis-generating and requires prospective validation.
The first stage of eosinophilic myocarditis is called the necrotizing phase. This stage of eosinophilic myocarditis of unknown cause is often fulminant and rapidly fatal, occurring predominantly in males. Here, we report a case of eosinophilic myocarditis in the acute necrotizing phase occurred without known cause in a 23-year-old Japanese female. Severe diffuse hypokinesis of the left ventricular wall motion (ejection fraction 19.3%), significant concentric edematous thickening of the left ventricular wall (20.1 mm in diastole) and a moderate amount of pericardial effusion (10 mm wide echo free space posteriorly) were revealed by echocardiography. Eosinophils were observed and degranulated eosinophilic cationic proteins were stained with antibody against eosinophilic cationic proteins (EG2) in the myocardial specimens obtained by myocardial biopsy. In spite of its severity, the disease resolved promptly with steroid therapy.
No takes yet. Share an insight, caveat, or question.
Uchino et al. (2000) conducted a case report in Acute eosinophilic myocarditis (n=1). Steroid therapy was evaluated on Disease resolution. Steroid therapy promptly resolved severe acute necrotizing eosinophilic myocarditis in a 23-year-old woman despite severe left ventricular dysfunction (ejection fraction 19.3%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: