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September 20, 2012Cardiology in the Young

Treatment with corticosteroids, an angiotensin-converting enzyme inhibitor, and warfarin led to a rapid and complete recovery of cardiac function and histology in a 15-year-old with eosinophilic myocarditis.

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Population

15-year-old adolescent with eosinophilic myocarditis presenting with flu-like symptoms, syncope, and cardiac…

Design

Case_report

Key result

Treatment with corticosteroids, an angiotensin-converting enzyme inhibitor, and warfarin led to a rapid and complete recovery of cardiac function and histology in a 15-year-old with eosinophilic myocarditis.

Authors

İAİlhan AslanMFMarcus FischerUniversity of GenevaKLKai Thorsten LaserUniversitätsklinikum Gießen und Marburg

Discussion

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Overview

Normal eosinophil counts do not exclude eosinophilic myocarditis in adolescents with acute heart failure; extends phenotypic spectrum but remains hypothesis-generating.

Key Points

  • To report the clinical course, diagnostic challenges, and successful treatment of acute eosinophilic myocarditis presenting without peripheral eosinophilia in an adolescent.
  • Evaluated a 15-year-old adolescent presenting with flu-like symptoms, syncope, and acute cardiac failure requiring inotropic support.
  • Performed cardiac magnetic resonance imaging and an endomyocardial biopsy, followed by comprehensive diagnostic work-up and literature review.
  • Endomyocardial biopsy confirmed eosinophilic myocarditis despite normal peripheral eosinophil counts at admission and procedure.
  • Cardiac magnetic resonance imaging demonstrated acute myocardial edema and late gadolinium enhancement in basal inferolateral segments.
  • Combined treatment with corticosteroids, an angiotensin-converting enzyme inhibitor, and warfarin achieved complete clinical, functional, and histological recovery.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 15-year-old adolescent presenting with eosinophilic myocarditis and cardiac failure.
I
Intervention
Corticosteroids, angiotensin-converting enzyme inhibitor, and warfarin
O
Outcome
Recovery of cardiac function and histology

Eosinophilic myocarditis can occur in adolescents and may present with normal peripheral eosinophil counts, but can be successfully treated with corticosteroids and heart failure therapy.

Cite This Study

Aslan et al. (2012) conducted a case report in Eosinophilic myocarditis (n=1). Corticosteroids, angiotensin-converting enzyme inhibitor, and warfarin was evaluated on Recovery of cardiac function and histology. Treatment with corticosteroids, an angiotensin-converting enzyme inhibitor, and warfarin led to a rapid and complete recovery of cardiac function and histology in a 15-year-old with eosinophilic myocarditis.

synapsesocial.com/papers/6ab33234fd339d704fb39b67https://doi.org/10.1017/s1047951112001199
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Eosinophilic myocarditis: two case reports and review of the literature2013 · 30 citations
  2. 2Eosinophilic Myocarditis: A Diagnostic Challenge and Treatment Dilemma - A Case Report2024 · 1 citations
  3. 3A case report of eosinophilic myocarditis and a review of the relevant literature2015 · 43 citations
  4. 4Eosinophilic myocarditis: characteristics, diagnostics and outcomes of a rare condition2016 · 6 citations
  5. 5Eosinophilic Myocarditis: From Bench to Bedside2024 · 18 citations