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December 1, 2013BMC Research NotesOpen Access

Corticosteroids yield limited cardiac improvement in eosinophilic myocarditis, emphasizing early diagnosis to prevent irreversible injury.

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Why the study?

Eosinophilic myocarditis is a rare and often under-diagnosed subtype of myocarditis with limited published cases and unclear diagnostic and therapeutic approaches.

Population

Two male patients with heart failure symptoms diagnosed with eosinophilic myocarditis

Design

Case reports and literature review

Key result

Two patients with eosinophilic myocarditis treated with corticosteroids showed little to mild improvement in cardiac function, emphasizing the need for early diagnosis to prevent irreversible myocardial injury.

Authors

JRJacques RizkallahADAngela DesautelsAMAmrit Malik

Discussion

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Overview

Corticosteroid response may be limited in established eosinophilic myocarditis; leaves open optimal timing and immunosuppression efficacy in prospective series.

Study Design

Type

Case Report (n=2)

Multicenter

No

Structured PICO

P
Population
Two male patients, aged 36 and 76, presenting with heart failure symptoms who were diagnosed with eosinophilic myocarditis.

Eosinophilic myocarditis is a rare, under-diagnosed condition where endomyocardial biopsy is the gold standard for diagnosis, though non-invasive imaging can aid early detection.

Limitations

  • Rarity of the disease leads to under-diagnosis
  • Endomyocardial biopsy has low sensitivity due to patchy disease nature and procedural risks
  • Therapies have yet to be validated in large prospective studies
  • Therapies for this disease have yet to be validated in large prospective studies.

Cite This Study

Rizkallah et al. (2013) conducted a case report in Eosinophilic myocarditis (n=2). Corticosteroids was evaluated on Cardiac function recovery. Two patients with eosinophilic myocarditis treated with corticosteroids showed little to mild improvement in cardiac function, emphasizing the need for early diagnosis to prevent irreversible myocardial injury.

synapsesocial.com/papers/6aa80f667ea4a4c47bb180d9https://doi.org/10.1186/1756-0500-6-538
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Eosinophilic Myocarditis: A Diagnostic Challenge and Treatment Dilemma - A Case Report2024 · 1 citations
  2. 2Eosinophilic myocarditis in an adolescent: a case report and review of the literature2012 · 16 citations
  3. 3Eosinophilic myocarditis: characteristics, diagnostics and outcomes of a rare condition2016 · 6 citations
  4. 4Eosinophilic myocarditis: case series and review of the literature.2025
  5. 5Diagnosis and treatment of eosinophilic myocarditis2021 · 61 citations