Key result
Chemotherapy with high-dose steroids enables survival in acute necrotizing eosinophilic myocarditis with ALL.
Why the study?
Acute necrotizing eosinophilic myocarditis is a rare and often fatal initial presentation of eosinophilic myocarditis with unique echocardiographic features and clinical course.
Case Report (n=1)
Acute necrotizing eosinophilic myocarditis can present as acute heart failure with severe diastolic dysfunction and preserved ejection fraction, and may be successfully treated with intensive cytotoxic chemotherapy and high-dose steroids.
Eosinophilic myocarditis is recognized by severe heart failure and marked eosinophilia infiltration resulting from different etiologies. Acute necrotizing eosinophilic myocarditis, the initial presentation of the disease, is rare and often fatal, with unique echocardiographic pictures, and followed by endocardial thrombosis and chronic endomyocardial fibrosis. We report a young female with acute lymphoblastic leukemia who presented fever and acute heart failure syndrome. The echocardiography showed severe left ventricle diastolic dysfunction with preserved ejection fraction. Systemic eosinophilia and the unique echocardiographic images made the diagnosis of acute necrotizing eosinophilic myocarditis. The patient survived after intensive cytotoxic chemotherapy including high-dose steroid.
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Liao et al. (2012) conducted a case report in Acute necrotizing eosinophilic myocarditis (n=1). Intensive cytotoxic chemotherapy including high-dose steroid was evaluated on Survival. Intensive cytotoxic chemotherapy including high-dose steroid led to the survival of a young woman with acute necrotizing eosinophilic myocarditis and acute lymphoblastic leukemia.
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