Key result
Free fatty acid insulin sensitivity inversely tracks beta cell secretion and MASH biomarkers in youth.
Observational
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In adolescents with obesity, adipose tissue insulin resistance is closely linked to hepatic injury markers and longitudinal changes in beta cell secretion.
In this study, we applied glucose, Cpeptide, and FFA minimal models to assess insulin sensitivities, insulin secretion, and lipolytic flux in NGT and IGT in adolescents with obesity. The results show that glucose and adipose tissue insulin sensitivities are strongly correlated with each other and with ALT plasma level. The longitudinal results show that changes in FFA insulin sensitivity are inversely associated with changes of beta cell secretion and with biomarkers of metabolic dysfunction-associated steatohepatitis.
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Bonet et al. (2024) conducted an observational in Obesity. Adipose tissue insulin resistance and FFA insulin sensitivity was evaluated on Correlation with ALT plasma level and biomarkers of metabolic dysfunction-associated steatohepatitis. Changes in free fatty acid insulin sensitivity were inversely associated with changes in beta cell secretion and biomarkers of metabolic dysfunction-associated steatohepatitis in obese adolescents.
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