Why the study?
Does a 900 mg loading dose of clopidogrel improve platelet inhibition compared to 600 mg or 300 mg in patients with coronary artery disease undergoing angiography?
Population
60 patients with suspected or documented coronary artery disease admitted for coronary angiography
Comparison
Clopidogrel 600 mg or 900 mg loading dose vs Clopidogrel 300 mg loading dose
Design
RCT, randomized, double-blinded
Follow-up
4 hours
Authors
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900 mg clopidogrel loading adds no platelet inhibition benefit over 600 mg; confirms 600 mg as sufficient and supports its use as standard in CAD angiography.
Does a 900 mg loading dose of clopidogrel improve platelet inhibition compared to 600 mg or 300 mg in patients with coronary artery disease undergoing angiography?
A 900-mg loading dose of clopidogrel does not provide additional platelet inhibition compared to a 600-mg dose due to limited absorption.
Beckerath et al. (2005) studied this question.
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