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July 12, 2024Nature MedicineOpen Access

An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score

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Why the study?

Existing scores to estimate HFpEF probability require imaging data that are often unavailable, motivating a screening model based exclusively on clinical variables to guide further testing.

Does the HFpEF-ABA score accurately estimate the probability of HFpEF using only clinical variables?

Population

Patients evaluated across derivation (n = 414) and multiple validation cohorts

Comparison

HFpEF-ABA score based on clinical variables

Design

Derivation and validation cohort study

Authors

YRYogesh N.V. ReddyRCRickey E. CarterVSVarun Sundaram

Discussion

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Overview

May aid HFpEF screening with routine variables; hypothesis-generating until prospectively validated.

Structured PICO

Does the HFpEF-ABA score accurately estimate the probability of HFpEF using only clinical variables?

P
Population
5,700 patients evaluated for heart failure with preserved ejection fraction (HFpEF) or unexplained dyspnea across multiple cohorts (derivation n=414; international validation n=736; unexplained dyspnea n=228; HF hospitalization n=456; Mayo Clinic n=790; Veteran Affairs n=3,076).
I
Intervention
HFpEF-ABA score (a clinical screening model using age, body mass index, and history of atrial fibrillation)
O
Outcome
Discrimination for HFpEF diagnosis (Area Under the Curve [AUC])

The HFpEF-ABA score provides a rapid, clinical-only screening tool for HFpEF using age, BMI, and atrial fibrillation history, demonstrating good diagnostic discrimination across multiple cohorts.

Cite This Study

Reddy et al. (2024) studied this question.

synapsesocial.com/papers/6a026f5619750436f6cb578bhttps://doi.org/10.1038/s41591-024-03140-1
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