Why the study?
Does thrombolytic therapy with tenecteplase improve outcomes in patients with massive pulmonary embolism and free floating right heart thrombus?
Does thrombolytic therapy with tenecteplase improve outcomes in patients with massive pulmonary embolism and free floating right heart thrombus?
Thrombolysis with tenecteplase can be an effective treatment strategy for free floating right heart thrombus associated with acute pulmonary embolism in carefully selected patients.
Answers are grounded in this paper and cite their sources.
May support tenecteplase in select massive PE with right heart thrombus; hypothesis-generating, needs prospective validation.
Free floating right heart thrombus is a rare phenomenon in the context of acute pulmonary embolism and it is associated with a poor outcome. The increased use of echocardiography has led to an increased detection of right heart thrombi. However, optimal management of free floating right heart thrombus remains controversial with no clear consensus. We present the case of a 74-year-old woman who presented to the emergency department with acute onset dyspnea on minimal exertion which had developed over a period of 1 day. A computed tomography of the chest demonstrated massive bilateral proximal pulmonary embolism. A bedside transthoracic echocardiography performed showed a moderately dilated, poorly functioning right ventricle with visible highly mobile serpiginous thrombus moving to and fro across the tricuspid valve. Thrombolytic therapy was immediately initiated with tenecteplase which resulted in excellent results. Although there is no clear consensus for the management of right heart thrombus associated with pulmonary embolism, thrombolysis is readily available and can be effective in carefully selected patients.
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Nkoke et al. (2015) studied this question.
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