July 22, 2004

Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

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Abstract

The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in PO2 are transduced to effect changes in gene expression.

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Gregg L. Semenza (Thu,) studied this question.

synapsesocial.com/papers/6a02af70daa0ebdf9f9e2bf8 https://doi.org/https://doi.org/10.1152/physiol.00001.2004

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1Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation2003 · 1,386 citations
2Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis2002 · 103 citations
3Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity <i>in vivo</i>2003 · 438 citations
4Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch2002 · 1,548 citations
5Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor2002 · 559 citations

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