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December 16, 2003Circulation

Association of the Metabolic Syndrome With History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey

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Why the study?

Is metabolic syndrome associated with a history of myocardial infarction and stroke in the general population?

Population

10,357 NHANES III subjects

Comparison

Metabolic syndrome vs Absence of metabolic syndrome

Design

Cross-sectional

Authors

JNJohn K. NinomiyaAmerican Diabetes AssociationGLGilbert L’ItalienBiohaven Pharmaceuticals (United States)Michael H. CriquiMichael H. CriquiUniversity of Vermont

Discussion

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Implication

May support metabolic syndrome assessment alongside prior events; leaves open causality and incident prediction in prospective data.

Structured PICO

Is metabolic syndrome associated with a history of myocardial infarction and stroke in the general population?

P
Population
10,357 NHANES III subjects
I
Intervention
Metabolic syndrome (defined by NCEP-ATP III criteria as ≥3 of 5 conditions: insulin resistance, abdominal obesity, hypertriglyceridemia, low HDL-C, and hypertension)
C
Comparator
Absence of metabolic syndrome
O
Outcome
History of myocardial infarction (MI), stroke, and either MI or stroke (MI/stroke)hard clinical

Metabolic syndrome is strongly and consistently associated with a prevalent history of myocardial infarction and stroke.

Cite This Study

Ninomiya et al. (2003) studied this question.

synapsesocial.com/papers/6a02fe6367f6ea5cc87575f3https://doi.org/10.1161/01.cir.0000108926.04022.0c
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1VALIDATION OF QUESTIONNAIRE INFORMATION ON RISK FACTORS AND DISEASE OUTCOMES IN A PROSPECTIVE COHORT STUDY OF WOMEN1986 · 999 citations
  2. 2Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation1998 · 15,332 citations
  3. 3Impaired Glucose Tolerance and the Likelihood of Nonfatal Stroke and Myocardial Infarction1998 · 50 citations
  4. 4Role of Insulin Resistance in Human Disease1988 · 12,163 citations
  5. 5Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)1993 · 27,987 citations